激肽释放酶相关肽酶（KLKs）与血栓形成轴的功能交集。
Functional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axis.
机构信息
Department of Biomedical Sciences, Florida State University, Tallahassee, 32306-4300, USA.
出版信息
Biol Chem. 2010 Apr;391(4):311-20. doi: 10.1515/BC.2010.024.
Abstract
A large body of emerging evidence indicates a functional interaction between the kallikrein-related peptidases (KLKs) and proteases of the thrombostasis axis. These interactions appear relevant for both normal health as well as pathologies associated with inflammation, tissue injury, and remodeling. Regulatory interactions between the KLKs and thrombostasis proteases could impact several serious human diseases, including neurodegeneration and cancer. The emerging network of specific interactions between these two protease families appears to be complex, and much work remains to elucidate it. Complete understanding how this functional network resolves over time, given specific initial conditions, and how it might be controllably manipulated, will probably contribute to the emergence of novel diagnostics and therapeutic agents for major diseases.
摘要
大量新出现的证据表明，激肽释放酶相关肽酶（KLKs）与血栓形成轴的蛋白酶之间存在功能相互作用。这些相互作用似乎与正常健康以及与炎症、组织损伤和重塑相关的病理学都有关。KLKs 和血栓形成蛋白酶之间的调节相互作用可能会影响几种严重的人类疾病，包括神经退行性疾病和癌症。这两种蛋白酶家族之间特定相互作用的新兴网络似乎很复杂，还有很多工作要做才能阐明这一点。完全了解这个功能网络在特定初始条件下随时间如何解决，以及如何对其进行可控操作，可能有助于为重大疾病开发新的诊断和治疗药物。
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