Kyoto University, Pharmacology, Kyoto 606-8507, Japan.
Expert Opin Ther Targets. 2010 Mar;14(3):265-73. doi: 10.1517/14728221003586836.
Cerebral aneurysms (CAs) are the main cause of life-threatening subarachnoid hemorrhage. Given its prevalence and endpoint, CA treatment is a public health issue. Effective medical treatment of CAs is lacking because the detailed mechanisms of CA formation are incompletely understood.
The aim of this contribution is to review recent articles about CA formation, to suggest the underlying mechanisms of CA formation, and to discuss potential therapeutic targets for treatment. Articles were collected by an internet search of PubMed using the keywords 'intracranial' or 'cerebral aneurysm'.
A review of articles about the pathogenesis of CA formation focusing on inflammation. Recent articles demonstrate that inflammation-related-molecule induction and inflammatory cell infiltration in CA walls and the close relationship between inflammatory responses and CA formation. From studies in experimental models, chronic inflammation triggered primarily by NF-kappaB activation in endothelial cells and subsequent macrophage infiltration have critical roles in CA formation. Inhibition of inflammation-related molecules in CA walls results in the decreased incidence of CA formation.
TAKE-HOME MESSAGE: Agents with anti-inflammatory activity (particularly anti- NF-kappaB effects) have potential as therapeutic drugs for CAs.
脑动脉瘤（CA）是危及生命的蛛网膜下腔出血的主要原因。鉴于其普遍性和终点，CA 的治疗是一个公共卫生问题。由于对 CA 形成的详细机制了解不完整，因此缺乏有效的医学治疗。
本综述的目的是回顾最近关于 CA 形成的文章，提出 CA 形成的潜在机制，并讨论治疗的潜在治疗靶点。文章通过在 PubMed 上使用“颅内”或“脑动脉瘤”等关键词进行互联网搜索收集。
一篇关于 CA 形成发病机制的综述，重点关注炎症。最近的文章表明，与炎症相关的分子诱导和炎症细胞在 CA 壁中的浸润，以及炎症反应与 CA 形成之间的密切关系。来自实验模型的研究表明，内皮细胞中 NF-κB 激活引发的慢性炎症以及随后的巨噬细胞浸润在 CA 形成中起关键作用。抑制 CA 壁中的炎症相关分子可降低 CA 的发生率。
具有抗炎活性（特别是抗 NF-κB 作用）的药物可能成为 CA 的治疗药物。
