肿瘤抑制因子 SIRTainty。

A tumor suppressor SIRTainty.

机构信息

Department of Pediatrics, Robert F Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

出版信息

Cancer Cell. 2010 Jan 19;17(1):5-6. doi: 10.1016/j.ccr.2009.12.032.

DOI:10.1016/j.ccr.2009.12.032

PMID:20129243

Abstract

Sirtuin deacetylases are linked to longevity, aging, and stress responses. In this issue of Cancer Cell, Kim et al. show that SIRT3 functions as a tumor suppressor by enhancing the expression of mitochondrial MnSOD. Loss of SIRT3 leads to increased mitochondrial ROS, which then enhances cellular transformation and tumor growth.

摘要

Sirtuin 去乙酰化酶与长寿、衰老和应激反应有关。在本期《癌细胞》中，Kim 等人表明，SIRT3 通过增强线粒体 MnSOD 的表达来发挥肿瘤抑制因子的作用。SIRT3 的缺失会导致线粒体 ROS 增加，从而增强细胞转化和肿瘤生长。