Department of Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
J Minim Invasive Gynecol. 2010 Jan-Feb;17(1):53-8. doi: 10.1016/j.jmig.2009.10.012.
To estimate the prevalence of benign, premalignant, and malignant endometrial polyps and the associated clinical risk factors for premalignant and malignant endometrial polyps.
Retrospective study (Canadian Classification II-3).
Teaching hospital.
Seven hundred sixty-six patients with endometrial polyps.
Hysteroscopic removal of endometrial polyps.
Patient clinical data were identified and analyzed. Frequency of premalignant and malignant histopathologic features in endometrial polyps was calculated. Clinical risk factors for premalignant and malignant endometrial polyps were analyzed. Endometrial polyps were histologically benign in most patients (96.21%). Hyperplasia with atypia in a polyp (premalignant polyp) was found in 3.26% of patients, and endometrial carcinoma in a polyp (malignant polyp) was detected in only 0.52% of patients. Independent variables that were significantly related to premalignant and malignant polyps (all p<.05) in a binary logistic regression analysis included polyp diameter (odds ratio [OR], 2.93; 95% confidence interval [CI], 1.191-7.20), menopause status (OR, 4.85; 95% CI, 2.09-11.27), and abnormal uterine bleeding (OR, 3.97; 95% CI, 1.71-9.18).
Polyp diameter larger than 1.0cm, menopause status, and abnormal uterine bleeding may increase the risk of premalignant and malignant endometrial polyps.
评估良性、癌前和恶性子宫内膜息肉的发生率，以及癌前和恶性子宫内膜息肉的相关临床危险因素。
回顾性研究（加拿大分类 II-3）。
教学医院。
766 名子宫内膜息肉患者。
宫腔镜下子宫内膜息肉切除术。
确定并分析患者的临床数据。计算子宫内膜息肉中癌前和恶性组织病理学特征的发生率。分析子宫内膜息肉癌前和恶性的临床危险因素。大多数患者的子宫内膜息肉组织学上为良性（96.21%）。在 3.26%的患者中发现息肉中存在增生伴异型（癌前息肉），而在仅 0.52%的患者中发现息肉中存在子宫内膜癌（恶性息肉）。在二元逻辑回归分析中，与癌前和恶性息肉显著相关的独立变量（均 p<.05）包括息肉直径（比值比[OR]，2.93；95%置信区间[CI]，1.191-7.20）、绝经状态（OR，4.85；95% CI，2.09-11.27）和异常子宫出血（OR，3.97；95% CI，1.71-9.18）。
直径大于 1.0cm 的息肉、绝经状态和异常子宫出血可能增加癌前和恶性子宫内膜息肉的风险。
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