Kraus A, Guerra-Bautista G, Espinoza G, Barojas E, Quiroz-Mercado H, Sanchez-Echeverri G, Alarcon-Segovia D
Department of Immunology and Rheumatology, Instituto Nacional de la Nutrición Salvador Zubirán, Mexico City, Mexico.
Br J Rheumatol. 1991 Apr;30(2):112-4. doi: 10.1093/rheumatology/30.2.112.
We completed ocular examination, including retinal fluoroangiography, in 19 unselected patients with diffuse systemic sclerosis (scleroderma) and compared the findings with those made in 50 consecutive patients with systemic lupus erythematosus, 18 with primary Sjögren's syndrome, 20 with mixed connective tissue disease, and 20 healthy women. Five of 19 scleroderma patients had atrophy of the retinal pigment epithelium (26.3%) while none of the controls and only four of the 88 (4.5%) patients with other connective tissue diseases (P less than 0.01) had this anomaly. Atrophy of the pigmented epithelium of the retina may occur in scleroderma as a result of damage of the choroidal plexus.
我们对19例未经挑选的弥漫性系统性硬化症（硬皮病）患者进行了眼科检查，包括视网膜荧光血管造影，并将检查结果与50例连续的系统性红斑狼疮患者、18例原发性干燥综合征患者、20例混合性结缔组织病患者以及20名健康女性的检查结果进行了比较。19例硬皮病患者中有5例（26.3%）存在视网膜色素上皮萎缩，而对照组无一例出现这种情况，在88例其他结缔组织病患者中仅有4例（4.5%）出现该异常（P<0.01）。视网膜色素上皮萎缩可能是由于脉络丛受损而在硬皮病中出现。
