Coşkun E, Zengin O, Kenan S, Kimyon G, Erdogan Er K, Okumus S, Mesut Onat A, Erbagcı I, Kısacık B
Gaziantep University Medicine School, Department of Ophthalmology, Gaziantep, Turkey.
Gaziantep University Medicine School, Department of Rheumatology, Gaziantep, Turkey.
Eye (Lond). 2016 Apr;30(4):588-92. doi: 10.1038/eye.2015.287. Epub 2016 Jan 22.
To investigate the choroidal thickness in patients with scleroderma and to compare them with healthy control subjects.
Forty-six patients with scleroderma (3 male and 43 female) and 31 healthy controls (6 male and 25 female) were included in the study. Twenty-five patients had limited-type and 21 patients had diffuse-type scleroderma. Only left eyes of the patients and control subjects were used in the analysis. Demographic features of all the patients and control subjects were recorded. Each subject underwent ophthalmological examinations including refraction, visual acuity, intraocular pressure, axial length (AXL) measurement, slit-lamp biomicroscopy, and fundus examination. Body mass index (BMI) was estimated for all participants.
There were no significant differences between the patients with scleroderma and the control subjects in terms of age, gender, BMI, mean AXL, and mean spherical equivalent refractive error (SE) (P=0.1, P=0.086, P=0.37, P=0.55, and P=0.072 respectively). The patients with scleroderma had significantly thinner nasal, temporal, and subfoveal choroid than the healthy control subjects (P1=0.012, P2=0.046, and P3<0.001, respectively). There were no significant differences between the patients with limited-type and diffuse-type scleroderma in terms of age, gender, BMI, mean AXL, mean SE, nasal, temporal, and subfoveal choroidal thicknesses (all P>0.05).
Choroidal thickness in patients with scleroderma was significantly less than healthy control subjects. Vasculopathy in scleroderma is characterized by obliteration of arterioles and reduced capillary density may cause atrophy of choroid in patients with scleroderma.
研究硬皮病患者的脉络膜厚度，并与健康对照者进行比较。
本研究纳入了46例硬皮病患者（3例男性和43例女性）和31例健康对照者（6例男性和25例女性）。25例患者为局限性硬皮病，21例患者为弥漫性硬皮病。分析仅采用患者和对照者的左眼。记录所有患者和对照者的人口统计学特征。每位受试者均接受眼科检查，包括验光、视力、眼压、眼轴长度（AXL）测量、裂隙灯生物显微镜检查和眼底检查。估算所有参与者的体重指数（BMI）。
硬皮病患者与对照者在年龄、性别、BMI、平均眼轴长度和平均等效球镜屈光不正（SE）方面无显著差异（分别为P = 0.1、P = 0.086、P = 0.37、P = 0.55和P = 0.072）。硬皮病患者的鼻侧、颞侧和黄斑下脉络膜明显比健康对照者薄（分别为P1 = 0.012、P2 = 0.046和P3 < 0.001）。局限性硬皮病患者和弥漫性硬皮病患者在年龄、性别、BMI、平均眼轴长度、平均SE、鼻侧、颞侧和黄斑下脉络膜厚度方面无显著差异（所有P>0.05）。
硬皮病患者的脉络膜厚度明显小于健康对照者。硬皮病中的血管病变以小动脉闭塞和毛细血管密度降低为特征，这可能导致硬皮病患者的脉络膜萎缩。
