Koziolek Michael J, Mueller Gerhard A
Department of Nephrology and Rheumatology, Georg-August-University Goettingen, Germany.
Atheroscler Suppl. 2009 Dec 29;10(5):56-8. doi: 10.1016/S1567-5688(09)71812-4.
Lipid-apheresis (LIPID-A) is highly effective in reduction of pro-atherosclerotic LDL-cholesterol and lipoprotein (a). It has been demonstrated in prospective and retrospective analyses to reduce major cardiovascular events. In addition to improvement of pro-atherosclerotic lipoprotein milieu, LIPID-A exerts pleiotropic effects on inflammation and micro-circulation. Several pro-inflammatory cyto- and chemokines as well as adhesion molecules are cleared by distinct LIPID-A methods. Moreover, a single LIPID-A can induce proliferative activity of circulating endothelial progenitor cells and by this way, enhance vascular repair capacity. Microcirculation is modified by LIPID-A by influencing the balance of vasoconstrictory and -dilatative mediators, plasma viscosity and erythrocyte aggregation resulting in an activation of functional capillary reserve and blood flow.
血脂分离术（LIPID - A）在降低促动脉粥样硬化的低密度脂蛋白胆固醇和脂蛋白（a）方面非常有效。前瞻性和回顾性分析已证明其可减少主要心血管事件。除了改善促动脉粥样硬化的脂蛋白环境外，血脂分离术（LIPID - A）还对炎症和微循环产生多效性作用。几种促炎细胞因子、趋化因子以及黏附分子可通过不同的血脂分离术方法清除。此外，单次血脂分离术（LIPID - A）可诱导循环内皮祖细胞的增殖活性，从而增强血管修复能力。血脂分离术（LIPID - A）通过影响血管收缩和舒张介质的平衡、血浆黏度和红细胞聚集来改变微循环，从而激活功能性毛细血管储备和血流。
