Ramunni Alfonso, Burzo Maria, Vernò Lucia, Brescia Paola
Division of Nephrology, Department of Internal and Public Medicine, University of Bari, Bari, Italy.
Atheroscler Suppl. 2009 Dec 29;10(5):53-5. doi: 10.1016/S1567-5688(09)71811-2.
LDL apheresis (LA), a technique employed to remove atherogenic lipoproteins, has been shown to exert a protective function on the vessel walls. This effect can be attributed to pleiotropic mechanisms that safeguard against endothelial dysfunction by reducing the concentrations of pro-inflammatory and pro-coagulation markers. Besides these actions, LA improves whole blood viscosity and endothelium-mediated vasodilation, and has a positive effect on the hemorheological picture, improving perfusion in the microcirculation. Although the short term effects on the functional component of the vascular damage seem to be temporary, long term effects on the morphological alterations have also been shown. It is still not clear which of the many proposed actions, or others still to be discovered, is the principal vessel protective mechanism.
低密度脂蛋白分离术（LA）是一种用于去除致动脉粥样硬化脂蛋白的技术，已被证明对血管壁具有保护作用。这种作用可归因于多效性机制，即通过降低促炎和促凝血标志物的浓度来预防内皮功能障碍。除了这些作用外，LA还可改善全血粘度和内皮介导的血管舒张，并对血液流变学状况产生积极影响，改善微循环灌注。尽管对血管损伤功能成分的短期影响似乎是暂时的，但对形态学改变的长期影响也已得到证实。目前尚不清楚众多已提出的作用中，或其他尚未被发现的作用中，哪一个是主要的血管保护机制。
