Moreno M J, Conde M V, de la Luz Fraile M, Fernández-Lomana H, López de Pablo A L, Marco E J
Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, Spain.
Brain Res. 1991 Jan 11;538(2):324-8. doi: 10.1016/0006-8993(91)90448-5.
Simultaneous lesions of dorsal and median raphe nuclei were induced after 15 days postjunctional supersensitivity to serotonin in isolated segments of cat middle cerebral artery. The same result was obtained when only the dorsal raphe nucleus was destroyed. The lesion of the median raphe nucleus brought about an increased contractile response to serotonin only at the three first doses used. The contractile response to noradrenaline was unaffected by these treatments. These results suggest the existence of a serotonergic innervation of the cat middle cerebral artery whose main origin might be the dorsal raphe nucleus.
在猫大脑中动脉分离段对5-羟色胺产生结后超敏反应15天后，诱导中缝背核和中缝正中核同时损伤。仅破坏中缝背核时也得到了相同的结果。中缝正中核损伤仅在最初使用的三个剂量下使对5-羟色胺的收缩反应增强。对去甲肾上腺素的收缩反应不受这些处理的影响。这些结果表明猫大脑中动脉存在5-羟色胺能神经支配，其主要起源可能是中缝背核。
