De Luca L A, Franci C R, Saad W A, Camargo L A, Antunes-Rodrigues J
Department of Physiology, School of Dentistry, Paulista State University, São Paulo, Brazil.
Brain Res Bull. 1991 Feb;26(2):203-10. doi: 10.1016/0361-9230(91)90227-b.
Two groups of rats with electrolytic lesions of the medial and upper septal area (MUL) or, alternatively, of the anteroventral portion of the third ventricle (AV3V) and a third group of sham-operated rats were water loaded and received three carbachol injections into the locus coeruleus according to the following schedule: 1) prelesion, 2) on the second postlesion day and 3) on the seventh postlesion day. Both MUL and AV3V lesions inhibited the carbachol-induced natriuresis on the second postlesion day. Recovery was almost complete after MUL but not after AV3V lesion on the seventh day. Water deprivation also reduced the carbachol-induced natriuresis but passive hydration of AV3V animals did not avoid the impairment induced by the lesion. Transient seizure phenomena such as clonic convulsions, salivation and analgesia subsequent to carbachol injection were not altered by the lesions.
两组大鼠分别接受了内侧和上部隔区（MUL）或第三脑室前腹侧部分（AV3V）的电解损伤，第三组为假手术大鼠，对这些大鼠进行水负荷，并按照以下时间表向蓝斑核注射三次卡巴胆碱：1）损伤前；2）损伤后第二天；3）损伤后第七天。MUL和AV3V损伤均在损伤后第二天抑制了卡巴胆碱诱导的利钠作用。第七天时，MUL损伤后恢复几乎完全，但AV3V损伤后未完全恢复。禁水也降低了卡巴胆碱诱导的利钠作用，但对AV3V损伤动物进行被动补液并不能避免损伤所致的损害。卡巴胆碱注射后出现的短暂癫痫现象，如阵挛性惊厥、流涎和镇痛，并未因损伤而改变。
