Fan M Y, Walker D H, Yu S R, Liu Q H
Department of Rickettsiology, Chinese Academy of Preventive Medicine, Beijing.
Rev Infect Dis. 1987 Jul-Aug;9(4):823-40.
Since 1949, information on rickettsial diseases in the People's Republic of China has been virtually nonexistent in the West. This is the first comprehensive review of the ecology and epidemiology of Chinese rickettsial diseases to be published outside the People's Republic. At least five rickettsioses exist in China: scrub typhus, murine typhus, epidemic typhus, Q fever, and one or more spotted fever-group (SFG) rickettsioses. Although epidemic typhus has been controlled and scrub typhus has abated in many areas, murine typhus, Q fever, and SFG rickettsiosis are important public health problems. Serologic surveys indicate high prevalences of antibodies to Coxiella burnetii, Rickettsia tsutsugamushi, and SFG rickettsiae in some regions; these rickettsiae have been isolated from humans, arthropods, and animals. Doxycycline has emerged as the best treatment for murine typhus, epidemic typhus, and scrub typhus. China offers both opportunities and challenges for the investigation and alleviation of the problems of rickettsial diseases.
自1949年以来，西方几乎没有关于中华人民共和国立克次氏体病的信息。这是第一篇在中华人民共和国境外发表的关于中国立克次氏体病生态学和流行病学的全面综述。中国至少存在五种立克次氏体病：恙虫病、鼠型斑疹伤寒、流行性斑疹伤寒、Q热以及一种或多种斑点热群（SFG）立克次氏体病。尽管流行性斑疹伤寒已得到控制，恙虫病在许多地区也有所减轻，但鼠型斑疹伤寒、Q热和SFG立克次氏体病仍是重要的公共卫生问题。血清学调查表明，某些地区人群中抗伯氏考克斯体、恙虫病东方体和SFG立克次氏体的抗体阳性率很高；这些立克次氏体已从人类、节肢动物和动物中分离出来。多西环素已成为治疗鼠型斑疹伤寒、流行性斑疹伤寒和恙虫病的最佳药物。中国在立克次氏体病问题的调查和缓解方面既存在机遇也面临挑战。
