Ingram L C, Fairclough D L, Furman W L, Sandlund J T, Kun L E, Rivera G K, Pui C H
Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Cancer. 1991 May 1;67(9):2262-8. doi: 10.1002/1097-0142(19910501)67:9<2262::aid-cncr2820670909>3.0.co;2-u.
Forty-five children with acute lymphoblastic leukemia or non-Hodgkin's lymphoma had cranial nerve palsy (CNP) as a complication of their disease. Twenty-two of these children had CNP initially and 23, at relapse, with or without previous hematologic relapse. Only one of the 23 patients with CNP at relapse was a long-term survivor. In contrast, 11 of the 22 children who had CNP initially survived in remission for 3+ months to 13+ years. Two factors are associated with an improved outcome for patients with CNP at diagnosis: treatment after 1979 (P less than 0.004) and male gender (P less than 0.01). Patients who received radiation therapy fared better than those for whom radiation was not given (disease-free survival at 2 years 53% versus 29%). The authors conclude that CNP signifies an aggressive or advanced disease requiring intensive systemic chemotherapy and that the role of irradiation should be examined for this group of patients.
45名患有急性淋巴细胞白血病或非霍奇金淋巴瘤的儿童出现颅神经麻痹（CNP），这是他们疾病的一种并发症。这些儿童中，22名最初就有CNP，23名在复发时出现CNP，无论之前是否有血液学复发。复发时出现CNP的23名患者中只有1名是长期幸存者。相比之下，最初就有CNP的22名儿童中有11名在缓解期存活了3个月以上至13年以上。诊断时，有两个因素与CNP患者预后改善相关：1979年以后开始治疗（P小于0.004）和男性性别（P小于0.01）。接受放射治疗的患者比未接受放射治疗的患者预后更好（2年无病生存率分别为53%和29%）。作者得出结论，CNP表明疾病具有侵袭性或处于晚期，需要强化全身化疗，并且应该对这组患者的放疗作用进行研究。
