Department of Pharmacy and Pharmacology, University of Bath, Bath, UK.
Neuroepidemiology. 2010;34(3):171-83. doi: 10.1159/000279334. Epub 2010 Feb 2.
A systematic review of literature published between 1980 and 2007, on the incidence of myasthenia gravis, was undertaken.
All relevant papers found through searches of Medline, Embase and Science Direct were critically appraised and an assessment was made of the reliability of the reported incidence data.
Thirty-one studies were included in the review, the majority of which investigated populations in Europe. The incidence rates reported were between 3.0 and 30.0/1,000,000/year. However, it is thought that the rates at the upper end of this range, reported by the prospective studies, provided the most accurate estimates. Overall, incidence rates have increased over time owing to a greater awareness of the disease and improved methods of diagnosis.
The most accurate estimate of incidence of myasthenia gravis was around 30/ 1,000,000/year. The incidence in children and adolescents aged 0-19 years was found to be between 1.0 and 5.0/ 1,000,000/year. The rates presented in this review are likely to be an underestimate of the true incidence rates, as mild cases will have been missed and cases in the elderly will have been misdiagnosed.
对 1980 年至 2007 年间发表的重症肌无力发病率的文献进行了系统综述。
通过对 Medline、Embase 和 Science Direct 的检索，对所有相关文献进行了批判性评价，并对报告的发病率数据的可靠性进行了评估。
综述共纳入 31 项研究，其中大多数研究调查了欧洲人群。报告的发病率在 3.0 至 30.0/100 万/年之间。然而，据认为，前瞻性研究报告的该范围上限的发病率提供了最准确的估计。总体而言，由于对该病的认识提高和诊断方法的改进，发病率随时间推移而增加。
重症肌无力发病率的最准确估计约为 30/100 万/年。0-19 岁儿童和青少年的发病率为 1.0 至 5.0/100 万/年。本综述中提出的发病率可能低估了真实的发病率，因为轻症病例可能被遗漏，老年病例可能被误诊。
