Oncology Unit, Casa Sollievo Sofferenza, S. Giovanni Rotondo, Italy.
Oncology. 2009;77 Suppl 1:75-89. doi: 10.1159/000258499. Epub 2010 Feb 2.
MicroRNAs (miRNAs) comprise an abundant class of small non-coding RNAs that act as important post-transcriptional regulators of gene expression. Accumulating evidence shows that aberrantly expressed miRNAs play important roles in human cancers and underscores them as potential targets for therapeutic intervention. Basic research has provided strong evidence about the role of miRNA as oncogenes and as tumor suppressor genes in cancer. In accord with this finding, miRNA-based cancer therapy is a very interesting field of investigation that offers the appeal of targeting multiple gene networks controlled by a single, aberrantly expressed miRNA. A new door in cancer research is opening and it may lead to the modulation of miRNAs.
MicroRNAs (miRNAs) 是一类丰富的小非编码 RNA，作为基因表达的重要转录后调控因子发挥作用。越来越多的证据表明，异常表达的 miRNAs 在人类癌症中发挥着重要作用，并凸显了它们作为治疗干预的潜在靶点。基础研究为 miRNA 作为癌基因和肿瘤抑制基因在癌症中的作用提供了有力证据。与此发现一致，基于 miRNA 的癌症治疗是一个非常有趣的研究领域，它提供了靶向由单个异常表达的 miRNA 控制的多个基因网络的吸引力。癌症研究的一扇新门正在打开，它可能导致 miRNA 的调节。
