近交系小鼠行为表型的发育变化：产后和幼年社交体验的作用。
Developmental shifts in the behavioral phenotypes of inbred mice: the role of postnatal and juvenile social experiences.
机构信息
Department of Psychology, Columbia University, Room 406 Schermerhorn Hall, 1190 Amsterdam Avenue, New York, NY, 10027, USA.
出版信息
Behav Genet. 2010 Mar;40(2):220-32. doi: 10.1007/s10519-010-9334-4. Epub 2010 Feb 4.
Abstract
The interaction between genotype and environment is an important feature of the process of development. We investigate this interaction by examining the influence of postnatal cross-fostering and post-weaning cross-housing on the behavioral development of 129S and B6 mice. Following cross-fostering, we found significant alterations in the frequency of maternal care as a function of maternal strain and pup type as well as interactions between these variables. In adulthood, we find there are sex-specific and strain-specific alterations in anxiety-like behavior as a function of rearing environment, with males exhibiting more pronounced rearing-induced effects. Mixed-strain housing of weanlings was found to lead to alterations in home-cage social and feeding behavior as well as changes in adult anxiety-like responses of 129S mice. Anxiety-like behavior in B6 mice was altered as a function of the interaction between housing condition and weaning weight. These data illustrate the complex pathways through which early and later social experiences may lead to variations in behavior.
摘要
基因型与环境的相互作用是发展过程的一个重要特征。我们通过考察产后交叉寄养和断奶后交叉饲养对 129S 和 B6 小鼠行为发育的影响来研究这种相互作用。在交叉寄养后，我们发现母鼠的抚育频率发生了显著变化，这与母鼠品系和幼鼠类型有关，并且这些变量之间存在相互作用。在成年期，我们发现饲养环境会导致焦虑样行为出现性别特异性和品系特异性变化，雄性表现出更明显的饲养诱导效应。幼鼠的混合品系饲养会导致其在笼内的社交和进食行为发生改变，并导致 129S 小鼠成年后的焦虑样反应发生变化。B6 小鼠的焦虑样行为会因饲养条件和断奶体重的相互作用而发生改变。这些数据说明了早期和后期社会经历可能通过复杂的途径导致行为发生变化。
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