Curley James P, Champagne Frances A
Department of Psychology, Columbia University, Room 406 Schermerhorn Hall, 1190 Amsterdam Avenue, New York, NY 10027, USA; Center for Integrative Animal Behavior, Columbia University, 1200 Amsterdam Avenue, New York, NY 10027, USA.
Front Neuroendocrinol. 2016 Jan;40:52-66. doi: 10.1016/j.yfrne.2015.11.001. Epub 2015 Nov 23.
Variation in maternal care can lead to divergent developmental trajectories in offspring with implications for neuroendocrine function and behavioral phenotypes. Study of the long-term outcomes associated with mother-infant interactions suggests complex mechanisms linking the experience of variation in maternal care and these neurobiological consequences. Through integration of genetic, molecular, cellular, neuroanatomical, and neuroendocrine approaches, significant advances in our understanding of these complex pathways have been achieved. In this review, we will consider the impact of maternal care on male and female offspring development with a particular focus on the issues of timing and mechanism. Identifying the period of sensitivity to maternal care and the temporal dynamics of the molecular and neuroendocrine changes that are a consequence of maternal care represents a critical step in the study of mechanism.
母性关怀的差异会导致后代出现不同的发育轨迹，对神经内分泌功能和行为表型产生影响。对母婴互动相关长期结果的研究表明，存在复杂机制将母性关怀差异的体验与这些神经生物学后果联系起来。通过整合遗传学、分子学、细胞学、神经解剖学和神经内分泌学方法，我们对这些复杂途径的理解取得了重大进展。在本综述中，我们将考虑母性关怀对雄性和雌性后代发育的影响，特别关注时间和机制问题。确定对母性关怀敏感的时期以及作为母性关怀结果的分子和神经内分泌变化的时间动态，是机制研究中的关键一步。
