益气养阴汤对不稳定型心绞痛患者生活质量的影响。

Effect of Yiqi Yangyin Decoction on the quality of life of patients with unstable angina pectoris.

机构信息

Cardiology Department of Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.

出版信息

Chin J Integr Med. 2010 Feb;16(1):13-8. doi: 10.1007/s11655-010-0013-3. Epub 2010 Feb 4.

DOI:10.1007/s11655-010-0013-3

PMID:20131030

Abstract

OBJECTIVE

To observe the effect of Yiqi Yangyin Decoction (, YQYYD) on the quality of life (QOL) of patients with unstable angina pectoris (UAP).

METHODS

A total of 108 patients with UAP of qi-yin deficiency syndrome confirmed by coronary angiography were enrolled and assigned to the treated group (treated with YQYYD and conventional therapy of Western medicine) and the control group (treated with conventional therapy of Western medicine), by the use of the PROC PLAN of the SAS 6.12 software, in a prospective, randomized, controlled design. The clinical total effective rate, symptom score, QOL scale [Seattle Angina Questionnaire (SAQ)] and incidence of important clinical events were defined as the observation indices to evaluate the interventional effect of YQYYD on the QOL of patients with UAP of the qi-yin deficiency syndrome.

RESULTS

During the study, three cases dropped out in the treated group, one case dropped out in the control group, and 104 cases, including 51 cases in the treatment group and 53 cases in the control group, finished the trial. After four weeks of treatment, the total clinical effective rates in the treated group and the control group were 80.4% and 75.5% respectively, and there was no obvious difference between them (P>0.05). However, the symptom score of the treated group (9.31 + or - 2.02) was significantly lesser than that of the control group (11.62 + or - 3.04, P<0.05), and the total score of the QOL scale of the treated group (68.76 + or - 5.74) was significantly higher than that of the control group (61.06 + or - 3.31, P<0.01). Among those in the treated group physical limitation, angina stability, angina frequency, and treatment satisfaction were significantly ameliorated when compared with the control group after treatment (P<0.05, P<0.01). The incidence of important clinical events in the treated group (3.9%) was lower than that in the control group (5.7%) during the 8-month follow-up period, but the difference was insignificant (P>0.05).

CONCLUSION

YQYYD could improve the clinical symptoms of patients with UAP of qi-yin deficiency syndrome and greatly improve their QOL.

摘要

目的

观察益气养阴方对不稳定型心绞痛（UAP）患者生活质量（QOL）的影响。

方法

共纳入 108 例经冠状动脉造影证实为气阴两虚证的 UAP 患者，采用 SAS 6.12 软件的 PROC PLAN 按前瞻性、随机、对照设计，分为治疗组（给予益气养阴方联合西医常规治疗）和对照组（给予西医常规治疗）。以临床总有效率、症状评分、QOL 量表[西雅图心绞痛量表（SAQ）]和重要临床事件发生率为观察指标，评价益气养阴方对 UAP 气阴两虚证患者 QOL 的干预效果。

结果

研究过程中，治疗组脱落 3 例，对照组脱落 1 例，共 104 例完成试验，其中治疗组 51 例，对照组 53 例。治疗 4 周后，治疗组和对照组的临床总有效率分别为 80.4%和 75.5%，两组间差异无统计学意义（P>0.05）。但治疗组症状评分（9.31±2.02）明显低于对照组（11.62±3.04，P<0.05），QOL 量表总分（68.76±5.74）明显高于对照组（61.06±3.31，P<0.01）。治疗后治疗组在躯体受限、心绞痛稳定、心绞痛发作频率和治疗满意度方面较对照组明显改善（P<0.05，P<0.01）。治疗组 8 个月随访期间重要临床事件发生率（3.9%）低于对照组（5.7%），但差异无统计学意义（P>0.05）。