组蛋白修饰和变体在乳腺癌中调控基因表达的作用。
The role of histone modifications and variants in regulating gene expression in breast cancer.
机构信息
Université de Toulouse, LBME, 118 route de Narbonne, 31062, Toulouse, France.
出版信息
J Mammary Gland Biol Neoplasia. 2010 Mar;15(1):19-33. doi: 10.1007/s10911-010-9167-z. Epub 2010 Feb 4.
PMID:20131086
Abstract
The role of epigenetic phenomena in cancer biology is increasingly being recognized. Here we focus on the mechanisms and enzymes involved in regulating histone methylation and acetylation, and the modulation of histone variant expression and deposition. Implications of these epigenetic marks for tumor development, progression and invasiveness are discussed with a particular emphasis on breast cancer progression.
摘要
表观遗传现象在癌症生物学中的作用正日益受到重视。本文重点讨论了调节组蛋白甲基化和乙酰化的机制和酶，以及组蛋白变体表达和沉积的调节。讨论了这些表观遗传标记对肿瘤发生、发展和侵袭的影响，特别强调了乳腺癌的进展。
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