Wan Xing, Liu Hong, Sun Yong, Zhang Jinlan, Chen Xianbing, Chen Ning
School of Medicine, Hubei University for Nationalities, Enshi, Hubei 445000, P.R. China.
China Meat Research Centre, Beijing 100068, P.R. China.
Oncol Lett. 2017 Jun;13(6):3997-4001. doi: 10.3892/ol.2017.6017. Epub 2017 Apr 10.
Strategies for the treatment of cancer remain unsatisfactory due to the poor understanding of the complicated underlying molecular mechanisms of carcinogenesis. A number of types of cancer exhibit a marked association with dietary habits and lifestyles. Therefore, the modulation of dietary habits or lifestyles may be an effective strategy for preventing the formation and progression of cancer. Proteins and polypeptides from soybean have been developed as healthcare products due to their marked activity in inhibiting the progression of cancer at various stages. Lunasin, containing 43 amino acid residues, is one such example of a soybean-derived polypeptide that has been demonstrated to exhibit marked anti-cancer activity. In the present review, studies of the underlying molecular mechanisms and potential advantages of lunasin in the prevention and treatment of cancer have been examined, to provide a theoretical reference for the development of natural product-based agents or healthcare products for the prevention and treatment of cancer.
由于对致癌作用复杂的潜在分子机制了解不足，癌症治疗策略仍不尽人意。许多类型的癌症与饮食习惯和生活方式显著相关。因此，调整饮食习惯或生活方式可能是预防癌症形成和进展的有效策略。大豆中的蛋白质和多肽因其在抑制癌症各阶段进展方面的显著活性而被开发为保健品。月见草素含有43个氨基酸残基，是一种已被证明具有显著抗癌活性的大豆衍生多肽。在本综述中，研究了月见草素在癌症预防和治疗中的潜在分子机制及优势，为开发基于天然产物的抗癌药物或保健品提供理论参考。
