Department of Obstetrics and Gynecology, Northwestern University, Chicago, IL 60611, USA.
Ultrasound Obstet Gynecol. 2010 Sep;36(3):324-7. doi: 10.1002/uog.7580.
The objective of this study was to determine whether amniotic sheets are associated with an increase in obstetric and neonatal morbidity.
Using a cohort study design, we identified all women with amniotic sheets, detected by a second-trimester ultrasound examination at a university hospital over a 6-year period. All women who received an ultrasound examination during that time, without a diagnosis of amniotic sheets, were also identified, and two women from among this group were randomly selected as controls for each case. Maternal and neonatal data were abstracted from the medical records, and maternal and neonatal morbidity were compared between the two groups.
One hundred and twenty-two women with pregnancies with a diagnosis of amniotic sheets were identified and compared to 244 women with pregnancies without a diagnosis of amniotic sheets. Composite obstetric morbidity was higher in women with amniotic sheets: 21.3% vs. 8.2% (relative risk (RR) 2.6; 95% CI, 1.5-4.5). Additionally, in women with amniotic sheets, neonates were more likely to be born with a birth weight of < 2500 g (RR 3.3; 95% CI, 1.8-6.4) and were more likely to be admitted to the neonatal intensive care unit (RR 2.3; 95% CI, 1.3-4.3). There were no perinatal deaths observed in either group.
Amniotic sheets are associated with an increase in adverse obstetric outcomes.
本研究旨在确定羊膜片是否与产科和新生儿发病率增加有关。
采用队列研究设计，我们确定了在一所大学医院进行的 6 年期间的中期超声检查中检测到的所有羊膜片的妇女。在此期间接受超声检查但未诊断为羊膜片的所有妇女也被确定，并且从该组中随机选择两名妇女作为每个病例的对照。从病历中提取了母亲和新生儿的数据，并比较了两组之间的母亲和新生儿发病率。
确定了 122 名患有羊膜片诊断的孕妇，并与 244 名未诊断为羊膜片的孕妇进行了比较。患有羊膜片的妇女的复合产科发病率较高：21.3%比 8.2%（相对风险（RR）2.6；95%置信区间，1.5-4.5）。此外，在患有羊膜片的妇女中，新生儿更有可能出生体重<2500g（RR 3.3；95%置信区间，1.8-6.4），更有可能被送入新生儿重症监护病房（RR 2.3；95%置信区间，1.3-4.3）。两组均未发生围产期死亡。
羊膜片与不良产科结局的增加有关。
