儿童移植后淋巴组织增生性疾病的扁桃体切除术。
Tonsillectomy in post-transplant lymphoproliferative disease in children.
机构信息
Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas 77030, USA.
出版信息
Laryngoscope. 2010 Mar;120(3):608-11. doi: 10.1002/lary.20799.
OBJECTIVES/HYPOTHESIS: To review the role of tonsillectomy in diagnosis and management of post-transplant lymphoproliferative disorder (PTLD).
STUDY DESIGN
Case series using a retrospective chart review.
METHODS
A retrospective review of post-transplant lymphoproliferative disease at a tertiary academic medical center from January 2004 to April 2008. Data extracted includes patients' gender, age at transplantation, year of transplantation and tonsillectomy, type of transplant, presenting symptoms, type of immunosuppression, and outcome.
RESULTS
Six out of 25 (24%) patients who underwent tonsillectomy were found to have PTLD. The patient's characteristics, gender, age at transplantation, year of transplantation and tonsillectomy, type of transplant, presenting symptoms, type of immunosuppression, and outcomes are discussed.
CONCLUSIONS
In our series, tonsillar hypertrophy, male gender, young age at transplantation, and liver transplantation were associated with higher rates of PTLD. Given the devastating nature of PTLD, early detection with tonsillectomy and institution of treatment is critical.
目的/假说：回顾扁桃体切除术在诊断和治疗移植后淋巴组织增生性疾病（PTLD）中的作用。
研究设计
使用回顾性图表审查的病例系列。
方法
对 2004 年 1 月至 2008 年 4 月在一家三级学术医疗中心的移植后淋巴组织增生性疾病进行回顾性研究。提取的数据包括患者的性别、移植时的年龄、移植年份和扁桃体切除术、移植类型、首发症状、免疫抑制类型以及结果。
结果
在接受扁桃体切除术的 25 例患者中，有 6 例（24%）发现患有 PTLD。讨论了患者的特征、性别、移植时的年龄、移植年份和扁桃体切除术、移植类型、首发症状、免疫抑制类型以及结果。
结论
在我们的系列中，扁桃体肥大、男性、移植时年龄较小和肝移植与更高的 PTLD 发生率相关。鉴于 PTLD 的破坏性性质，早期通过扁桃体切除术发现并进行治疗至关重要。
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