Leenman E E, Mukhina M S, Nasyrov A R
Arkh Patol. 2009 Nov-Dec;71(6):44-6.
The paper provides a morphological and immunohistochemical description of hepatic angiomyolipoma in a 29-year-old woman. Microscopically, it is a tumor with trabecular and diffuse growth patterns, which consists of polygonal cells with pleomorphic nuclei and extensive cytoplasm accumulated around the nucleus. Immunohistochemical study is of crucial importance in making the diagnosis. The tumor cells coexpress smooth muscle actin and the melanin markers: HMB-45, melan A, and MITF. The proliferative activity of the tumor is very low (Ki-67 index < 1%). According to the present views, angiomyolipoma belongs to perivascular epithelioid cell tumors (PEComas).
本文对一名29岁女性的肝脏血管平滑肌脂肪瘤进行了形态学和免疫组织化学描述。显微镜下，它是一种具有小梁状和弥漫性生长模式的肿瘤，由多角形细胞组成，细胞核多形性，大量细胞质聚集在细胞核周围。免疫组织化学研究对诊断至关重要。肿瘤细胞共表达平滑肌肌动蛋白和黑色素标记物：HMB-45、黑色素A和小眼畸形转录因子（MITF）。肿瘤的增殖活性非常低（Ki-67指数<1%）。根据目前的观点，血管平滑肌脂肪瘤属于血管周上皮样细胞瘤（PEComas）。
