Ma T K, Tse M K, Tsui W M, Yuen K T
Institutes of Pathology, Queen Elizabeth Hospital, Hong Kong.
Acta Cytol. 1994 Mar-Apr;38(2):257-60.
Fine needle aspiration diagnosis of hepatic angiomyolipoma has been reported rarely. Below we report one such case diagnosed by examination of a cell block. The presence of epithelioid smooth muscle cells, mature adipocytes, thick-walled vessels and extramedullary hematopoiesis established the diagnosis. It was further substantiated by positive staining of the epithelioid cells for muscle-specific actin (HHF-35). The epithelioid cells were also immunoreactive with a melanocytic marker, HMB-45, but not with desmin, vimentin, cytokeratin or S-100 protein. HMB-45 might prove to be a sensitive marker for the epithelioid smooth muscle component of the tumor. The advantage of the routine use of a cell block in fine needle aspiration is emphasized.
细针穿刺诊断肝血管平滑肌脂肪瘤的报道很少。以下我们报告一例通过细胞块检查诊断的此类病例。上皮样平滑肌细胞、成熟脂肪细胞、厚壁血管和髓外造血的存在确立了诊断。上皮样细胞对肌肉特异性肌动蛋白（HHF-35）呈阳性染色进一步证实了这一点。上皮样细胞也与黑素细胞标志物HMB-45免疫反应，但与结蛋白、波形蛋白、细胞角蛋白或S-100蛋白无免疫反应。HMB-45可能是该肿瘤上皮样平滑肌成分的敏感标志物。强调了在细针穿刺中常规使用细胞块的优势。
