Department of Psychiatry, University of California San Francisco, San Francisco, California, USA.
Am J Addict. 2010 Jan-Feb;19(1):47-52. doi: 10.1111/j.1521-0391.2009.00009.x.
Chronic cocaine use has been shown to significantly decrease buprenorphine concentrations in the blood with potential for adverse events and poor treatment response. In this study, we investigated whether a similar drug interaction occurred between cocaine and methadone. In a retrospective analysis, methadone pharmacokinetics were compared for those who were either regular cocaine users (N = 16) or with intermittent or no cocaine use (N = 23). Participants who used cocaine regularly showed a significant decrease in C(min) (p = .04) and a trend for decreased AUC (p = .09) and more rapid methadone clearance (p = .08). Regular cocaine use may adversely impact treatment outcomes for opioid dependence in those receiving methadone maintenance by decreasing methadone exposure.
慢性可卡因使用已被证明会显著降低血液中的丁丙诺啡浓度，从而可能导致不良事件和治疗反应不佳。在这项研究中，我们调查了可卡因和美沙酮之间是否存在类似的药物相互作用。在回顾性分析中，比较了经常使用可卡因的患者（N = 16）和美沙酮间歇性或不使用者（N = 23）的美沙酮药代动力学。经常使用可卡因的患者表现出 C(min) 显著降低（p =.04），AUC 降低趋势（p =.09）和更快的美沙酮清除率（p =.08）。在接受美沙酮维持治疗的患者中，经常使用可卡因可能会通过降低美沙酮暴露来对阿片类药物依赖的治疗结果产生不利影响。
