Department of Psychiatry, University of California, San Francisco, San Francisco, California, USA.
Am J Addict. 2010 Jan-Feb;19(1):4-16. doi: 10.1111/j.1521-0391.2009.00005.x.
Drug interactions are a leading cause of morbidity and mortality. Methadone and buprenorphine are frequently prescribed for the treatment of opioid addiction. Patients needing treatment with these medications often have co-occurring medical and mental illnesses that require medication treatment. The abuse of illicit substances is also common in opioid-addicted individuals. These clinical realities place patients being treated with methadone and buprenorphine at risk for potentially toxic drug interactions. A substantial literature has accumulated on drug interactions between either methadone or buprenorphine with other medications when ingested concomitantly by humans. This review summarizes current literature in this area.
药物相互作用是发病率和死亡率的主要原因。美沙酮和丁丙诺啡常用于治疗阿片类药物成瘾。需要用这些药物治疗的患者通常同时患有需要药物治疗的合并症和精神疾病。阿片类药物成瘾者滥用非法物质也很常见。这些临床现实使接受美沙酮和丁丙诺啡治疗的患者面临潜在的有毒药物相互作用的风险。大量文献积累了人类同时摄入美沙酮或丁丙诺啡与其他药物之间的药物相互作用。这篇综述总结了这一领域的现有文献。
