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肺静脉起源的房性心动过速经导管消融成功后的长期结果:无晚期心房颤动。

Long-term outcome following successful catheter ablation of atrial tachycardia originating from the pulmonary veins: absence of late atrial fibrillation.

机构信息

Department of Cardiology, Royal Melbourne Hospital and the Department of Medicine, University of Melbourne, Melbourne, Australia.

出版信息

J Cardiovasc Electrophysiol. 2010 Jul;21(7):747-50. doi: 10.1111/j.1540-8167.2009.01698.x. Epub 2010 Feb 1.

Abstract

OBJECTIVES

This study aimed to characterize the long-term outcome and incidence of atrial fibrillation (AF) in patients following catheter ablation of focal atrial tachycardia (AT) from the pulmonary veins (PV).

BACKGROUND

Although both AT and AF may originate from ectopic foci within PVs, it is unknown whether PV AT patients subsequently develop AF.

METHODS

Twenty-eight patients with 29 PV ATs (14%) from a consecutive series of 194 patients who underwent RFA for focal AT were included. Patients with concomitant AF prior to the index procedure were excluded.

RESULTS

The minimum follow-up duration was 4 years; mean age 38 +/- 18 years with symptoms for 6.5 +/- 10 years, having tried 1.5 +/- 0.9 antiarrhythmic drugs. The distribution of foci was: left superior 12 (41%), right superior 10 (34%), left inferior 5 (17%), and right inferior 2 (7%). The focus was ostial in 93% and 2-4 cm distally within the vein in 7%. Mean tachycardia cycle length was 364 +/- 90 ms. Focal ablation was performed in 25 of 28 patients. There were 6 recurrences with 5 from the original site. Twenty-six patients were available for long-term clinical follow-up. At a mean of 7.2 +/- 2.1 years, 25 of 26 (96%) were free from recurrence off antiarrhythmic drugs. No patients developed AF.

CONCLUSIONS

Focal ablation for tachycardia originating from the PVs is associated with long-term freedom from both AT and AF. Therefore, although PV AT and PV AF share a common anatomic distribution, PV AT is a distinct clinical entity successfully treated with focal RFA and not associated with AF in the long term.

摘要

目的

本研究旨在描述从肺静脉(PV)消融局灶性房性心动过速(AT)后,患者的长期结局和房颤(AF)发生率。

背景

尽管 AT 和 AF 均可起源于 PV 内的异位灶,但尚不清楚 PV AT 患者是否随后会发生 AF。

方法

连续 194 例接受 RFA 治疗局灶性 AT 的患者中,纳入 28 例(14%)有 29 例 PV AT。排除在索引手术前有合并 AF 的患者。

结果

最小随访时间为 4 年;平均年龄为 38 +/- 18 岁,症状持续时间为 6.5 +/- 10 年,曾尝试过 1.5 +/- 0.9 种抗心律失常药物。病灶分布为:左上部 12 例(41%)、右上 10 例(34%)、左下部 5 例(17%)和右下部 2 例(7%)。93%的病灶位于开口处,7%的病灶位于静脉内 2-4cm 处。心动过速周期长度的平均值为 364 +/- 90ms。28 例患者中有 25 例行局灶消融。有 6 例复发,其中 5 例来自原病灶。26 例患者可进行长期临床随访。平均随访 7.2 +/- 2.1 年后,26 例患者(96%)无心律失常药物复发性心动过速。无患者发生 AF。

结论

起源于 PV 的心动过速的局灶消融与 AT 和 AF 的长期无复发相关。因此,尽管 PV AT 和 PV AF 具有共同的解剖分布,但 PV AT 是一种明确的临床实体,通过局灶性 RFA 治疗有效,且在长期内与 AF 无关。

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