食管恶性肿瘤的晚期表现：一个多民族东南亚人群的观察结果。

Late presentation of esophageal cancer: observations in a multiracial South-East Asian population.

机构信息

Department of Surgery, Faculty of Medicine, University of Malaya, Malaysia.

出版信息

J Dig Dis. 2010 Feb;11(1):28-33. doi: 10.1111/j.1751-2980.2009.00410.x.

DOI:10.1111/j.1751-2980.2009.00410.x

PMID:20132428

Abstract

OBJECTIVE

Esophageal cancer (ECA) is an important cancer in Malaysia. The aim of the study is to review the demographic data and clinical presentation of patients with ECA seen at the University of Malaya Medical Centre, Kuala Lumpur.

METHODS

Patients with histologically proven ECA were recruited for the study. Patients' case notes, endoscopy and operating theater records were reviewed. All cases were histologically confirmed.

RESULTS

A total of 143 patients with ECA was diagnosed between 1998 and 2003. The mean age of the patients was 63.1 +/- 12.1 years with a male : female ratio of 1.8:1. Of these 50.3 percent were Indians, 32.9 percent, Chinese and 16.8 percent Malays. The overall hospital-based prevalence rates per 100 000 admissions according to races were: Malay; 23.5, Chinese; 57.4 and Indian; 134.1. The location of the tumors was: upper; 16 (11.2%) middle; 52 (36.4%) and lower; 75 (52.4%). The histological type of ECA were: squamous cell carcinomas; 113 (79.0%) and adenocarcinomas; 30 (21.0%). The ECA stage at diagnosis, was: II; 18 (12.6%), III; 23 (16.1%) and IV; 102 (71.3%). Only 24 (16.8%) patients underwent surgery and13 (9.1%) were considered curative. Overall 114 (79.7%) patients underwent palliative endoscopic stenting and six (4.2%) were given other palliative therapy including radiotherapy.

CONCLUSIONS

Squamous cell cancer was the predominant type. ECA presents late in our patients and only a minority of patients underwent curative surgery.

摘要

目的

食管癌（ECA）是马来西亚的一种重要癌症。本研究旨在回顾在吉隆坡马来亚大学医学中心就诊的 ECA 患者的人口统计学数据和临床表现。

方法

招募了经组织学证实的 ECA 患者进行本研究。回顾了患者的病历、内窥镜和手术室记录。所有病例均经组织学证实。

结果

1998 年至 2003 年间共诊断出 143 例 ECA 患者。患者的平均年龄为 63.1±12.1 岁，男女比例为 1.8:1。其中 50.3%为印度人，32.9%为中国人，16.8%为马来人。根据种族，每 10 万入院人次的医院患病率分别为：马来人 23.5，中国人 57.4，印度人 134.1。肿瘤位置：上段 16 例（11.2%），中段 52 例（36.4%），下段 75 例（52.4%）。ECA 的组织学类型为：鳞状细胞癌 113 例（79.0%），腺癌 30 例（21.0%）。诊断时的 ECA 分期为：Ⅱ期 18 例（12.6%），Ⅲ期 23 例（16.1%），Ⅳ期 102 例（71.3%）。仅 24 例（16.8%）患者接受手术治疗，13 例（9.1%）患者被认为可治愈。共有 114 例（79.7%）患者接受姑息性内镜支架置入术，6 例（4.2%）患者接受其他姑息性治疗，包括放疗。