Department of Pharmacology, Maulana Azad Medical College, New Delhi, India.
Int J Tuberc Lung Dis. 2010 Mar;14(3):374-6.
Severe malnutrition is known to affect the pharmacokinetics of isoniazid (INH) in children. However, the effect of moderate malnutrition, which may be more prevalent, is not known. INH was administered to 20 children with tuberculosis at a single dose of 5 mg/kg, and serial blood samples were collected. The serum INH concentrations were higher in the undernourished group but the pharmacokinetic parameters were comparable with those in the normal nutrition group. Weight gain was significantly more in the undernourished group after 1 month of treatment. The study suggests that INH pharmacokinetics may not be significantly altered in children with moderate malnutrition.
严重营养不良已知会影响异烟肼（INH）在儿童中的药代动力学。然而，可能更为普遍的中度营养不良的影响尚不清楚。给 20 名结核病儿童单次服用 5mg/kg 的异烟肼，并采集连续的血样。在营养不足的组中，血清异烟肼浓度较高，但药代动力学参数与正常营养组相似。治疗 1 个月后，营养不足组的体重增加明显更多。该研究表明，中度营养不良的儿童中，异烟肼的药代动力学可能没有明显改变。
