Departament de Química Analítica i Química Orgànica, Universitat Rovira i Virgili, Campus Sescelades, Marcel.lí Domingo s/n, 43007 Tarragona, Spain.
J Chromatogr A. 2010 Mar 5;1217(10):1575-82. doi: 10.1016/j.chroma.2010.01.037. Epub 2010 Jan 18.
The synthesis of high specific surface area sorbents (HXLPP-WCX) in the form of hypercrosslinked polymer microspheres with narrow particle size distributions, average particle diameters around 6 microm, and weak cation-exchange (WCX) character, is described. The WCX character arises from carboxylic acid moieties in the polymers, derived from the comonomer methacrylic acid. A novel HXLPP-WCX sorbent with an attractive set of chemical and physical properties was then used in an off-line solid-phase extraction (SPE) protocol for the selective extraction of a group of basic compounds from complex environmental samples, a priority being the clean separation of the basic compounds of interest from acidic compounds and interferences. The separation power of the new sorbent for basic pharmaceuticals was compared to two commercially available, mixed-mode sorbents, namely Oasis WCX and Strata-X-CW. Under identical experimental conditions, HXLPP-WCX was found to deliver both higher capacity and better selectivity in SPE than either of the two commercially available materials. In an optimised SPE protocol, the HXLPP-WCX sorbent gave rise to quantitative and selective extractions of low microg l(-1) levels of basic pharmaceuticals present in 500 ml of river water and 250 ml of effluent waste water.
高比表面积吸附剂（HXLPP-WCX）的合成形式是超交联聚合物微球，具有窄的粒径分布，平均粒径约为 6 微米，具有弱阳离子交换（WCX）特性。这种 WCX 特性源于聚合物中的羧酸基团，来源于共聚单体甲基丙烯酸。然后，一种具有吸引力的化学和物理性质的新型 HXLPP-WCX 吸附剂被用于离线固相萃取（SPE）方案，用于从复杂的环境样品中选择性地提取一组碱性化合物，优先从酸性化合物和干扰物中分离出感兴趣的碱性化合物。新型吸附剂对碱性药物的分离能力与两种市售的混合模式吸附剂（Oasis WCX 和 Strata-X-CW）进行了比较。在相同的实验条件下，与两种市售材料相比，HXLPP-WCX 在 SPE 中表现出更高的容量和更好的选择性。在优化的 SPE 方案中，HXLPP-WCX 吸附剂能够定量和选择性地从 500 毫升河水和 250 毫升废水样品中提取低至微克/升水平的碱性药物。
