Luan ShiHai, Zhuang DongXiao, Sun LinLin, Huang Feng-Ping
Department of Neurosurgery, Huashan Hospital affiliated to Fudan University, Shanghai Neurosurgical Center, The 3rd ward, 12 Middle Wulumuqi Road, Shanghai 200040, PR China.
Clin Neurol Neurosurg. 2010 May;112(4):362-4. doi: 10.1016/j.clineuro.2010.01.006. Epub 2010 Feb 4.
Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle has been identified as a novel and distinctive type of primary central nervous system neoplasm. In this report, we present a case with RGNT arising from the right cerebellar hemisphere. A 30-year-old female patient complained of headache for a five-year duration. Preoperative MRI revealed a well-circumscribed, cystic-solid lesion with hypo-intensity on T1-weighted image, hyper-intensity on T2-weighted image, and significant dot-like enhancement after IV contrast. Gross total resection was achieved in this case via suboccipital retro-sigmoidal approach, and RGNT was confirmed in the final histopathological diagnosis. RGNT of the fourth ventricle is a rare, benign tumor with an excellent prognosis. Operation is recommended as the prior protocol of treatment, and the follow-up MRI is necessary to evaluate the long-term prognostic effects. Currently, only one case of progression or recurrence has been reported in the postoperative course.
第四脑室的菊形团形成型胶质神经元肿瘤（RGNT）已被确认为一种新型且独特的原发性中枢神经系统肿瘤。在本报告中，我们呈现了一例起源于右小脑半球的RGNT病例。一名30岁女性患者主诉头痛长达五年。术前MRI显示一个边界清晰的囊实性病变，在T1加权图像上呈低信号，在T2加权图像上呈高信号，静脉注射造影剂后有明显的点状强化。该病例通过枕下乙状窦后入路实现了肿瘤全切，最终组织病理学诊断证实为RGNT。第四脑室的RGNT是一种罕见的良性肿瘤，预后良好。建议将手术作为首选治疗方案，并且需要进行术后MRI随访以评估长期预后效果。目前，术后病程中仅报道过一例进展或复发的病例。
