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与口服抗精神病药相比,长效抗精神病药需要在多大程度上更有效,才能被开处方?

How much more effective do depot antipsychotics have to be compared to oral antipsychotics before they are prescribed?

机构信息

Klinik und Poliklinik für Psychiatrie und Psychotherapie, Technische Universität München, Germany.

出版信息

Eur Neuropsychopharmacol. 2010 Apr;20(4):276-9. doi: 10.1016/j.euroneuro.2010.01.001. Epub 2010 Feb 4.

DOI:10.1016/j.euroneuro.2010.01.001
PMID:20133108
Abstract

Antipsychotic depots are less frequently prescribed than oral compounds. In an experimental study involving N=106 psychiatrists we studied how much more effective with respect to relapse prevention depot antipsychotics have to be compared to oral antipsychotics before they are chosen for prescription. Most psychiatrists have to judge depot as clearly superior with respect to relapse prevention before they recommend it to patients. If psychiatrists judge depot as unpleasant for the patients and do not see much need for checking their patients' compliance they are less likely to prescribe depot. Other psychiatrist-related factors (e.g. age, gender, and work experience) did not influence attitudes toward depot.

摘要

抗精神病药长效针剂的处方频率低于口服制剂。在一项涉及 106 名精神科医生的实验研究中,我们研究了长效针剂相对于口服制剂在预防复发方面需要高出多少才能被选择用于处方。大多数精神科医生必须判断长效针剂在预防复发方面明显优于口服制剂,然后才会向患者推荐。如果精神科医生认为长效针剂对患者来说不愉快,并且认为没有必要经常检查患者的依从性,那么他们就不太可能开长效针剂。其他与精神科医生相关的因素(如年龄、性别和工作经验)并没有影响他们对长效针剂的态度。

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