Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom.
Endocrinology. 2010 Apr;151(4):1581-7. doi: 10.1210/en.2009-1088. Epub 2010 Feb 4.
The association between low birth weight and cardiovascular disease is amplified by the development of obesity. We explored the effects of postnatal high-fat (HF) feeding in dexamethasone (Dex)-programmed rats, in which prenatal glucocorticoid overexposure is associated with reduced birth weight and adult glucose intolerance. Male Wistar rats exposed to Dex or vehicle (Veh) during the last week of gestation were weaned onto HF or control diets for 6 months. Dex-exposed animals were of lower birth weight and showed catch-up growth by 7 wk. There were no differences in obesity or hyperinsulinaemia between Dex-HF and Veh-HF animals. However, Dex-HF animals had increased hepatic triglyceride content compared with Veh-HF animals. mRNA transcript profiles in adipose tissue revealed depot-specific changes in the expression of genes involved in fatty acid esterification and triglyceride synthesis and storage with prenatal Dex exposure. Thus, antenatal glucocorticoid overexposure in rats does not confer increased sensitivity to HF diet-induced obesity, but increases susceptibility to fatty liver. This may be due to depot-specific-programmed alterations in fat metabolism in adipose tissue.
低出生体重与心血管疾病之间的关联因肥胖的发展而加剧。我们探讨了在接受地塞米松（Dex）处理的大鼠中，产后高脂肪（HF）喂养的影响，其中产前糖皮质激素暴露与出生体重降低和成年期葡萄糖耐量降低有关。在妊娠最后一周接受 Dex 或载体（Veh）处理的雄性 Wistar 大鼠在断奶后接受 HF 或对照饮食 6 个月。Dex 处理的动物出生体重较低，但在 7 周时出现追赶性生长。Dex-HF 和 Veh-HF 动物之间在肥胖或高胰岛素血症方面没有差异。然而，与 Veh-HF 动物相比，Dex-HF 动物的肝甘油三酯含量增加。脂肪组织中的 mRNA 转录谱显示，与产前 Dex 暴露相关的脂肪酸酯化和甘油三酯合成和储存相关的基因在脂肪组织中的表达存在特定部位的变化。因此，大鼠产前糖皮质激素过度暴露不会增加对 HF 饮食诱导肥胖的敏感性，但会增加脂肪肝的易感性。这可能是由于脂肪组织中特定部位的脂肪代谢编程改变所致。
