MYC 调控“预后不良”转移性癌细胞状态。
MYC regulation of a "poor-prognosis" metastatic cancer cell state.
机构信息
Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
出版信息
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3698-703. doi: 10.1073/pnas.0914203107. Epub 2010 Feb 4.
Abstract
Gene expression signatures are used in the clinic as prognostic tools to determine the risk of individual patients with localized breast tumors developing distant metastasis. We lack a clear understanding, however, of whether these correlative biomarkers link to a common biological network that regulates metastasis. We find that the c-MYC oncoprotein coordinately regulates the expression of 13 different "poor-outcome" cancer signatures. In addition, functional inactivation of MYC in human breast cancer cells specifically inhibits distant metastasis in vivo and invasive behavior in vitro of these cells. These results suggest that MYC oncogene activity (as marked by "poor-prognosis" signature expression) may be necessary for the translocation of poor-outcome human breast tumors to distant sites.
摘要
基因表达特征被临床用作预测工具，以确定局部乳腺癌患者发生远处转移的个体风险。然而，我们并不清楚这些相关的生物标志物是否与调节转移的共同生物学网络有关。我们发现，c-MYC 癌蛋白协调调节 13 种不同的“预后不良”癌症特征的表达。此外，在人乳腺癌细胞中功能性失活 MYC 特异性地抑制这些细胞体内的远处转移和体外的侵袭行为。这些结果表明，MYC 癌基因活性（如“预后不良”特征表达所标记的）可能是将预后不良的人类乳腺癌肿瘤转移到远处部位所必需的。
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