Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan.
Vet Pathol. 2010 Mar;47(2):339-42. doi: 10.1177/0300985809358428. Epub 2009 Dec 31.
At necropsy, an 11-year-old Japanese Black cow with anemia, leukocytopenia, and progressive hind limb ataxia had marked diffuse splenomegaly and multiple masses in the thoracic vertebrae. Histologically, neoplastic erythrophagocytic histiocytes were in the splenic red pulp, vertebral masses, and blood vessels of the liver and lungs. The spinal cord was compressed by the vertebral masses. Clinicopathological, macroscopic, and histologic findings were consistent with hemophagocytic histiocytic sarcoma. Vertebral involvement with spinal cord compression and resultant hind limb ataxia is an unusual presentation for this tumor, which has been described mainly in dogs and cats.
剖检时，一头患有贫血、白细胞减少症和进行性后肢共济失调的 11 岁日本黑牛出现明显弥漫性脾肿大和多个胸椎肿块。组织病理学上，脾红髓、椎体重块以及肝肺血管中有肿瘤性噬血细胞组织细胞。脊椎肿块压迫脊髓。临床病理、大体和组织学检查结果与噬血细胞性组织细胞肉瘤一致。该肿瘤主要见于犬猫，脊椎受累伴脊髓压迫和随后的后肢共济失调的表现较为罕见。
