Friedrichs Kristen R, Young Karen M
Department of Pathobiological Sciences, University of Wisconsin School of Veterinary Medicine, 2015 Linden Drive, Madison, WI 53706, USA.
Vet Clin Pathol. 2008 Mar;37(1):121-8. doi: 10.1111/j.1939-165X.2008.00005.x.
Mild nonregenerative anemia was detected in a 9-year-old neutered male domestic shorthair cat during a routine examination. Bone marrow core biopsy revealed erythroid hyperplasia; however, a specific cause was not identified. Over the next 8 months the anemia progressed, eventually becoming mildly regenerative, and moderate thrombocytopenia developed. On ultrasonographic examination, marked splenomegaly, mild hepatomegaly, and abdominal lymphadenopathy were found. Cytologic evaluation of splenic aspirates revealed increased numbers of mildly to moderately pleomorphic histiocytes that frequently had phagocytosed RBCs, leukocytes, and occasionally platelets. Histopathologic examination of the spleen and liver revealed effacement of splenic architecture by a histiocytic sarcoma (HS), and neoplastic histiocytes in hepatic sinusoids. A second bone marrow aspirate revealed neoplastic infiltration by similar cells. The histiocytes in all tissues were mildly to moderately pleomorphic and markedly erythrophagocytic. The immunophenotype of histiocytes in the spleen was CD1c(-)/CD11b(+)/CD18(+)/MHC-II(+), supporting a macrophage cell lineage. The clinical, pathologic, and immunophenotypic findings in this cat were similar to those in hemophagocytic HSs in dogs. To our knowledge, this is the first report of a HS of purported macrophage phenotype in a cat.
在一次常规检查中，一只9岁已绝育的雄性家养短毛猫被检测出患有轻度非再生性贫血。骨髓芯活检显示红细胞增生；然而，未确定具体病因。在接下来的8个月里，贫血病情进展，最终变为轻度再生性贫血，并出现中度血小板减少症。超声检查发现脾脏明显肿大、肝脏轻度肿大和腹部淋巴结病。脾脏穿刺液的细胞学评估显示，轻度至中度多形性组织细胞数量增加，这些细胞经常吞噬红细胞、白细胞，偶尔也吞噬血小板。脾脏和肝脏的组织病理学检查显示，组织细胞肉瘤（HS）使脾脏结构消失，肝血窦中有肿瘤性组织细胞。第二次骨髓穿刺显示有类似细胞的肿瘤浸润。所有组织中的组织细胞均为轻度至中度多形性，且明显具有红细胞吞噬作用。脾脏中组织细胞的免疫表型为CD1c(-)/CD11b(+)/CD18(+)/MHC-II(+)，支持巨噬细胞谱系。这只猫的临床、病理和免疫表型结果与犬噬血细胞性HSs的结果相似。据我们所知，这是首例关于猫的具有所谓巨噬细胞表型的HS的报道。
