Unidade de Biologia Microvascular e Inflamação, Instituto de Medicina Molecular, Instituto de Bioquímica, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
Clin Hemorheol Microcirc. 2010;44(1):63-74. doi: 10.3233/CH-2010-1253.
In the sixties and seventies, erythrocytes or red blood cells (RBCs) were extensively studied. Much has been learnt particularly concerning their metabolism and gas transporter function.In the past decade, the use of new approaches and methodologies, such as proteomic analysis, has contributed for a renewed interest on the erythrocyte. Recent studies have provided us with a more detailed and comprehensive picture on the composition and organization of its cellular membrane that will be the main subject of this minireview. Unexpectedly, it has been recognized that this cell expresses several adhesion molecules on its surface, like other cellular types such blood circulating cells or endothelial cells. Taking into consideration the cellular functions of the erythrocyte, the clarification of the role of those adhesion molecules may in the future open new horizons for the biological significance of this cellular player.
在六、七十年代，人们对红细胞（erythrocytes 或 RBCs）进行了广泛的研究。特别在其新陈代谢和气体转运蛋白功能方面取得了丰硕的研究成果。在过去的十年中，新方法和新技术（如蛋白质组学分析）的应用，重新引起了人们对红细胞的兴趣。最近的研究为我们提供了关于其细胞膜组成和组织的更详细和全面的信息，这将是本次综述的主要内容。出乎意料的是，人们发现这种细胞在其表面表达了几种黏附分子，就像其他细胞类型一样，如循环血细胞或内皮细胞。考虑到红细胞的细胞功能，阐明这些黏附分子的作用可能会为这个细胞角色的生物学意义开辟新的前景。
