Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Eur Neurol. 2010;63(3):144-8. doi: 10.1159/000280763. Epub 2010 Feb 5.
The purpose of this study was to investigate the relationship of muscle MRI findings and gait disturbance in myotonic dystrophy type 1 (DM1) patients. Thirteen patients with DM1 were evaluated by manual muscle strength test and muscle MRI of the lower limb. All DM1 patients presenting with foot drop showed high intensity signals in the tibialis anterior muscles on T1-weighted imaging (p < 0.001). The patients presenting with gait disturbance showed high intensity signals in the semimembranosus, vastus intermedius and gastrocnemius medialis muscles, too. Disturbance of the gastrocnemius lateralis muscles was mild in all DM1 patients. The patients without gait disturbance showed no abnormalities, especially in tibialis anterior muscles on muscle MRI. Muscle MRI is useful for the detection of pathological muscles in DM1 patients with gait disturbance.
本研究旨在探讨肌萎缩性侧索硬化症 1 型（DM1）患者肌肉 MRI 表现与步态障碍的关系。13 例 DM1 患者进行了下肢肌肉磁共振成像（MRI）和徒手肌力检查。所有出现足下垂的 DM1 患者，在 T1 加权成像上，胫骨前肌有高强度信号（p < 0.001）。有步态障碍的患者，半膜肌、股中间肌和腓肠肌内侧也有高强度信号。所有 DM1 患者的腓肠肌外侧肌均有轻度障碍。无步态障碍的患者，肌肉 MRI 未见异常，特别是胫骨前肌。肌肉 MRI 有助于发现有步态障碍的 DM1 患者的病理性肌肉。
