Analysis Group, Inc, 111Huntington Avenue 10th floor, Boston, MA 02199, USA.
J Occup Environ Med. 2010 Feb;52(2):115-24. doi: 10.1097/JOM.0b013e3181cb5b10.
To assess effects of antidepressant treatment compliance on health care and workplace costs.
By using workplace survey data linked to two employers' health care claims, employees with depression/antidepressant claims were categorized into noncompliant/compliant groups. Annualized costs were compared between compliance groups, for the employees with antidepressant use and a subset diagnosed with depression.
Among antidepressant users (N = 1224), medical costs were not statistically different for compliant versus noncompliant patients; drug costs were higher for compliant patients, primarily because of antidepressants' costs. Similar associations were observed among depressed patients (N = 488). Absenteeism costs were lower for compliant patients with antidepressant use ($3857 vs $4,907, P = 0.041) and among depressed patients ($3976 vs $5899, P = 0.047). Presenteeism costs were higher for depressed compliant patients ($19,170 vs $15,829, P = 0.011).
Increased compliance with antidepressants is significantly associated with reduced absenteeism costs.
评估抗抑郁药物治疗依从性对医疗保健和工作场所成本的影响。
通过使用与两家雇主医疗保健索赔相关联的工作场所调查数据，将有抑郁/抗抑郁药物索赔的员工分为不依从/依从组。比较了在使用抗抑郁药物的员工和一部分被诊断为抑郁症的员工中，依从性组之间的年度成本。
在使用抗抑郁药物的患者中（N=1224），依从性患者与不依从性患者的医疗费用无统计学差异；依从性患者的药物费用较高，主要是因为抗抑郁药物的费用。在抑郁症患者中（N=488）也观察到了类似的关联。使用抗抑郁药物的依从性患者的旷工成本较低（$3857 与$4907，P=0.041），抑郁症患者的旷工成本也较低（$3976 与$5899，P=0.047）。有抑郁症状的依从性患者的出勤成本较高（$19170 与$15829，P=0.011）。
增加抗抑郁药物的依从性与减少旷工成本显著相关。
