State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.
Org Biomol Chem. 2010 Feb 21;8(4):811-21. doi: 10.1039/b923123d. Epub 2010 Jan 4.
The allene-diyne natural product nemotin was synthesized for the first time through an enantioselective route with the stereogenic center at the lactone moiety derived from l-glutamic acid and the allene axis constructed from the corresponding propargylic tosylate, and the absolute configuration was thus established as (4S,5aS).
首次通过手性中心位于内酯部分（由 L-谷氨酸衍生而来）和烯丙基轴（由相应的炔丙基对甲苯磺酸酯构建而成）的对映选择性路线合成了全烯二炔天然产物 nemotin，并确定了其绝对构型为 (4S,5aS)。
