镇静对声学过度刺激引起的暂时性阈移的影响。

Sedation effect on temporary threshold shift induced by acoustic overstimulation.

作者信息

Hildesheimer M, Henkin Y, Muchnik C, Anafi R, Sahartov E, Rubinstein M

机构信息

School of Health Professions, Department of Communication Disorders, Speech, Language and Hearing, Sackler Faculty of Medicine, Tel Aviv University, Chaim Sheba Medical Center, Tel Hashomer, Israel.

出版信息

Hear Res. 1991 Jan;51(1):161-6. doi: 10.1016/0378-5955(91)90014-z.

DOI:10.1016/0378-5955(91)90014-z

PMID:2013542

Abstract

The mechanism by which noise damages the inner ear has not as yet been fully elucidated. Experiments were done to study the influence of the sedation in temporary threshold shift (TS) induced by acoustic overstimulation, as barbiturates were found to improve the brain's tolerance to ischemia. Four groups of guinea pigs (GP) were used. The temporary TS was decreased with the reduction of the temperature in awake, as well as sedated, sound-exposed GP. However, the temporary TS in the sedated, but normothermic GP was as great as in the awake, normothermic group. The high temperature counteracts the protection effect of the sedation in nose-induced hearing loss.

摘要

噪声损害内耳的机制尚未完全阐明。由于发现巴比妥类药物可提高大脑对缺血的耐受性，因此进行了实验以研究镇静对声学过度刺激引起的暂时性阈移（TS）的影响。使用了四组豚鼠（GP）。在清醒以及镇静且暴露于声音的豚鼠中，随着温度降低，暂时性TS减小。然而，镇静但体温正常的豚鼠中的暂时性TS与清醒、体温正常组中的一样大。高温抵消了镇静在噪声性听力损失中的保护作用。