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耳蜗敏感性的变化不会改变初级听神经纤维不同自发放电率类别的相对阈值。

Changes in cochlear sensitivity do not alter relative thresholds of different spontaneous rate categories of primary auditory nerve fibres.

作者信息

Robertson D, Wilson S A

机构信息

Department of Physiology, University of Western Australia, Nedlands.

出版信息

Hear Res. 1991 Jan;51(1):29-32. doi: 10.1016/0378-5955(91)90004-s.

DOI:10.1016/0378-5955(91)90004-s
PMID:2013543
Abstract

The CF thresholds of three different spontaneous firing rate categories of single auditory nerve fibres were measured in guinea pigs with widely differing cochlear sensitivities. The CF thresholds for all fibres were compared to the CAP thresholds at the same frequencies. The relationship between single fibre CF threshold and CAP thresholds for the three different fibre categories remained unchanged despite the very wide range of absolute CAP thresholds. The widely ranging CAP thresholds in these animals were probably due to varying degrees of outer hair cell pathology and these data therefore support the notion that in normal animals, the origin of differences in threshold between fibres with different spontaneous rates, lies in the properties of the inner hair cells and/or their synapses with afferent dendrites.

摘要

在具有广泛不同耳蜗敏感性的豚鼠中,测量了三种不同自发放电率类别的单根听神经纤维的特征频率(CF)阈值。将所有纤维的CF阈值与相同频率下的复合动作电位(CAP)阈值进行比较。尽管CAP阈值的绝对范围非常广泛,但三种不同纤维类别的单纤维CF阈值与CAP阈值之间的关系保持不变。这些动物中CAP阈值的广泛差异可能是由于外毛细胞病理程度的不同,因此这些数据支持这样一种观点,即在正常动物中,具有不同自发放电率的纤维之间阈值差异的根源在于内毛细胞及其与传入树突突触的特性。

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