Prijs V F, Keijzer J, Versnel H, Schoonhoven R
ENT Department, Leiden University Hospital, The Netherlands.
Hear Res. 1993 Dec;71(1-2):190-201. doi: 10.1016/0378-5955(93)90034-x.
Spontaneous activity was analysed in auditory-nerve fibres innervating normal and noise-damaged cochleas. Spike occurrences were conceived as point processes. Joint interval distributions and serial correlation coefficients reveal a weak history effect for succeeding intervals. The point process is regarded as a renewal and the recovery function, being proportional to the hazard function, is determined from the interval probability density function. In 29 out of 60 fibres the latter shows peculiarities which result in a deviation from a monotonically increasing recovery function. For three fibers of low characteristic frequency the interval probability function shows an oscillatory pattern and for 26 fibres this function exhibits an early, sharp peak around 1.1 ms irrespective of characteristic frequency, spontaneous rate, or cochlear damage. The recovery function is not different between fibres with normal and those with abnormally high thresholds and exhibits an exponential recovery with one time constant of average value 1.6 ms. Bursting activity is found in only one fibre from the abnormally high threshold group.
对支配正常和噪声损伤耳蜗的听神经纤维的自发活动进行了分析。脉冲发放被视为点过程。联合间隔分布和序列相关系数揭示了后续间隔的弱历史效应。点过程被视为更新过程，且恢复函数与风险函数成正比，由间隔概率密度函数确定。在60根纤维中的29根中，后者表现出一些特性，导致其偏离单调递增的恢复函数。对于三根特征频率较低的纤维，间隔概率函数呈现振荡模式；对于26根纤维，无论特征频率、自发率或耳蜗损伤情况如何，该函数在1.1毫秒左右都有一个早期的尖锐峰值。阈值正常和阈值异常高的纤维之间的恢复函数没有差异，并且呈现出具有平均时间常数1.6毫秒的指数恢复。在阈值异常高的组中，仅在一根纤维中发现了爆发性活动。
