Lehmann L J, Schollmeyer A, Stoeve J, Scharf H-P
Orthopädisch-Unfallchirurgisches Zentrum, Universitätsklinik Mannheim.
Z Orthop Unfall. 2010 Jan;148(1):90-4. doi: 10.1055/s-0029-1186112. Epub 2009 Oct 19.
The biochemical changes associated with rotator cuff tearing are still unclear. The aim of this study is to assess whether concentrations of matrix metalloproteinase in the synovial fluid are specifically altered in shoulders with torn rotator cuff tendons.
Synovial fluid was extracted via arthroscopy in 21 patients with complete rotator cuff tears (RCTs). The control group was composed of 21 patients without complete tears. The catabolic cartilage metabolism markers MMP-1 (collagenase), MMP-3 (stromelysin1) and MMP-13 (collagenase3) were quantified by an ELISA test and these results were then statistically analysed using SAS.
The mean concentration of the 21 samples with rotator cuff tears shows a higher concentration of MMP 3 (2601.73 ng/mL vs. 1775.67 ng/mL) and MMP 13 (2.69 ng/mL vs. 2.35 ng/mL) as well as a significantly higher concentration of MMP 1 (p=0.0047) in the control group.
A significant variation in the concentration of catabolic cartilage enzymes in the synovial fluid in patients with and without rotator cuff tears could not be found. Nonetheless, there is a bias for the MMP-3 and MMP-13 values, which makes a conductive influence in the aetiology of osteoarthritis probable.
与肩袖撕裂相关的生化变化仍不明确。本研究的目的是评估肩袖肌腱撕裂的肩部滑液中基质金属蛋白酶的浓度是否有特异性改变。
通过关节镜检查从21例肩袖完全撕裂（RCT）患者中提取滑液。对照组由21例无完全撕裂的患者组成。通过酶联免疫吸附测定试验对分解代谢性软骨代谢标志物MMP-1（胶原酶）、MMP-3（基质溶解素1）和MMP-13（胶原酶3）进行定量，然后使用SAS对这些结果进行统计分析。
21例肩袖撕裂样本的平均浓度显示，MMP 3（2601.73 ng/mL对1775.67 ng/mL）和MMP 13（2.69 ng/mL对2.35 ng/mL）的浓度较高，且对照组中MMP 1的浓度显著更高（p = 0.0047）。
未发现肩袖撕裂患者与未患肩袖撕裂患者的滑液中分解代谢性软骨酶浓度存在显著差异。尽管如此，MMP-3和MMP-13值存在偏差，这可能对骨关节炎的病因产生传导性影响。
