Oto-rhino-laryngology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Head Neck. 2010 Nov;32(11):1467-72. doi: 10.1002/hed.21348.
The objective of our study was to analyze the incidence and location of second and subsequent tumors in patients after an index head and neck carcinoma.
A retrospective study was made by reviewing clinical data prospectively collected from 3631 patients with head and neck cancer. Incidence, location, and histology of the second, third, and fourth tumors was evaluated.
During the follow-up, 839 second tumors, 147 third tumors, and 35 fourth tumors were diagnosed. The annual hazard ratio was 3.8% for second tumors, 5.1% for third tumors, and 7.8% for fourth tumors. The risk of second and subsequent neoplasms remained constant throughout the follow-up. There were significant differences in the risk of appearance between the second and third tumors (p < .0001), and between the third and fourth tumors (p = .005).
Patients with a second tumor after an index head and neck carcinoma have an increased risk for developing subsequent tumors.
本研究的目的在于分析头颈部癌症患者首次肿瘤确诊后的第二及后续肿瘤的发病情况和发病部位。
通过对 3631 例头颈部癌症患者前瞻性收集的临床数据进行回顾性研究，评估第二、第三和第四肿瘤的发病率、发病部位和组织学特征。
随访期间共诊断出 839 例第二肿瘤、147 例第三肿瘤和 35 例第四肿瘤。第二肿瘤的年危险比为 3.8%，第三肿瘤为 5.1%，第四肿瘤为 7.8%。第二和后续肿瘤的风险在整个随访期间保持不变。第二和第三肿瘤的发病风险（p <.0001）以及第三和第四肿瘤的发病风险（p =.005）存在显著差异。
首次头颈部癌症确诊后发生第二肿瘤的患者，发生后续肿瘤的风险增加。
