Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA.
Prostate. 2010 Jun 1;70(8):883-8. doi: 10.1002/pros.21122.
Aspirin, other non-steroidal anti-inflammatory drugs (NSAIDs), and statins have been associated with lower risk of prostate cancer and its progression, though results have been inconsistent.
Data from 140 men with prostate cancer enrolled in a Phase 2 clinical trial of selenium to prevent prostate cancer progression were analyzed to determine association between aspirin, other NSAIDs, or statin use with baseline serum prostate-specific antigen (PSA) levels and PSA velocity (rate of PSA change over time) using repeated measures over an average follow-up time of 3.2 years. Multiple linear regression and mixed effects models were used to model the association of medication use with PSA at baseline and with PSA velocity, respectively.
Baseline PSA levels were significantly lower in aspirin users compared to non-users (5.17 ng/ml vs. 7.58 ng/ml, P = 0.001). This association was statistically significant in never smokers (aspirin users vs. non-users: 4.19 ng/ml vs. 8.24 ng/ml, P = 0.004) but not in ever smokers (aspirin users vs. non-users: 5.52 ng/ml vs. 7.3 ng/ml, P = 0.101). Statin and other NSAID use was not associated with baseline PSA. Aspirin, statin, or other NSAID use at baseline demonstrated a non-significant negative association with PSA velocity.
These findings support an effect of aspirin use on PSA, particularly among never smokers. However, they do not suggest a protective effect on the disease and support previous findings that aspirin use may mask accurate measurement of PSA warranting consideration of washout procedures prior to testing.
阿司匹林、其他非甾体抗炎药（NSAIDs）和他汀类药物与前列腺癌风险降低及其进展相关，但结果不一致。
对参加硒预防前列腺癌进展的 2 期临床试验的 140 名前列腺癌患者的数据进行了分析，以确定阿司匹林、其他 NSAIDs 或他汀类药物的使用与基线前列腺特异性抗原（PSA）水平和 PSA 速度（PSA 随时间变化的速率）之间的关系，平均随访时间为 3.2 年，采用重复测量。使用多元线性回归和混合效应模型分别对药物使用与基线 PSA 和 PSA 速度的关系进行建模。
与非使用者相比，阿司匹林使用者的基线 PSA 水平显著降低（5.17ng/ml 与 7.58ng/ml，P=0.001）。在从不吸烟者中，这种相关性具有统计学意义（阿司匹林使用者与非使用者：4.19ng/ml 与 8.24ng/ml，P=0.004），但在吸烟者中则没有（阿司匹林使用者与非使用者：5.52ng/ml 与 7.3ng/ml，P=0.101）。他汀类药物和其他 NSAID 的使用与基线 PSA 无关。基线时使用阿司匹林、他汀类药物或其他 NSAID 与 PSA 速度呈非显著负相关。
这些发现支持阿司匹林使用对 PSA 的影响，尤其是在从不吸烟者中。然而，它们并没有表明对疾病有保护作用，并且支持之前的发现，即阿司匹林的使用可能会掩盖 PSA 的准确测量，因此在进行测试之前需要考虑冲洗程序。
