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Small molecule macroarray construction via palladium-mediated carbon-carbon bond-forming reactions: highly efficient synthesis and screening of stilbene arrays.

作者信息

Frei Reto, Blackwell Helen E

机构信息

Department of Chemistry, University of Wisconsin-Madison, 1101 University Ave., Madison, WI 53706-1322, USA.

出版信息

Chemistry. 2010 Mar 1;16(9):2692-5. doi: 10.1002/chem.200903445.

DOI:10.1002/chem.200903445
PMID:20135652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3181100/
Abstract
摘要

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Use of quorum sensing inhibitors to interfere with biofilm formation and development in Burkholderia multivorans and Burkholderia cenocepacia.使用群体感应抑制剂干扰多食伯克霍尔德菌和洋葱伯克霍尔德菌复合群中的生物膜形成与发展。
Res Microbiol. 2009 Mar;160(2):144-51. doi: 10.1016/j.resmic.2008.12.003. Epub 2008 Dec 31.
3
Organic chemistry: Molecular diversity by design.有机化学：通过设计实现分子多样性。
Nature. 2009 Jan 8;457(7226):153-4. doi: 10.1038/457153a.
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Synthesis of natural-product-like molecules with over eighty distinct scaffolds.具有八十多种不同骨架的类天然产物分子的合成。
Angew Chem Int Ed Engl. 2009;48(1):104-9. doi: 10.1002/anie.200804486.
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Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria.拓展对话：从天然自诱导物到调节革兰氏阴性菌群体感应的非天然类似物。
Chem Soc Rev. 2008 Jul;37(7):1432-47. doi: 10.1039/b703021p. Epub 2008 Jun 2.
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Prospect of metal-catalyzed C-C forming cross-coupling reactions in modern solid-phase organic synthesis.金属催化的C-C键形成交叉偶联反应在现代固相有机合成中的前景
J Comb Chem. 2008 Jul-Aug;10(4):487-97. doi: 10.1021/cc800020b. Epub 2008 May 31.
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Modulation of bacterial quorum sensing with synthetic ligands: systematic evaluation of N-acylated homoserine lactones in multiple species and new insights into their mechanisms of action.用合成配体调节细菌群体感应：对多种物种中N-酰基高丝氨酸内酯的系统评估及其作用机制的新见解。
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Drugs for bad bugs: confronting the challenges of antibacterial discovery.对抗耐药菌的药物：应对抗菌药物研发的挑战
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