Katz K, Mechlis-Frish S, Cohen I J, Horev G, Zaizov R, Lubin E
Department of Orthopedic Surgery, Beilinson Medical Center, Petah Tiqva, Israel.
J Bone Joint Surg Am. 1991 Apr;73(4):513-7.
Of thirty-four occurrences of bone pain in seventeen children and young adults who had type-I Gaucher disease, twenty-five were finally diagnosed as bone crises. On the basis of a bone scan with technetium-99m methylene diphosphonate, a correct diagnosis of bone crisis was made for twenty-three occurrences, with a sensitivity of 0.92. At the onset of a crisis, the bone scan typically showed decreased uptake of radionuclide at the involved site. After six weeks, a repeat bone scan of the long bones showed a ring of increased uptake surrounding an area of decreased uptake. At six months, the appearance of the bones on the radionuclide scan was normal.
在17名患有I型戈谢病的儿童和年轻成年人所出现的34次骨痛中，有25次最终被诊断为骨危象。基于用99m锝亚甲基二膦酸盐进行的骨扫描，对23次骨危象做出了正确诊断，灵敏度为0.92。在危象发作时，骨扫描通常显示受累部位放射性核素摄取减少。六周后，对长骨进行的重复骨扫描显示，在摄取减少区域周围有一圈摄取增加的影像。六个月时，放射性核素扫描显示的骨骼外观正常。
