Laboratory of Panic and Respiration, Institute of Psychiatry, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Expert Rev Neurother. 2010 Feb;10(2):291-303. doi: 10.1586/ern.09.161.
Thanks to brain imaging great advances have been made concerning the comprehension of neural substrates related to panic disorder (PD). This article aims to: review the recent functional MRI (fMRI) studies concerning PD; correlate the PD fMRI neurobiological findings with the fear neurocircuitry hypothesis; discuss the fear neurocircuitry hypothesis and link it to cognitive-behavior therapy findings; and comment on fMRI study limitations and suggest methodological changes for future research. As a whole, there is increasing evidence that brain structures such as the prefrontal cortex, the anterior cingulate cortex and limbic areas (hippocampus and amygdala) might play a major role in the panic response.
由于脑成像技术的巨大进步，人们对与惊恐障碍（PD）相关的神经基质的理解有了很大的进展。本文旨在：回顾有关 PD 的最近的功能磁共振成像（fMRI）研究；将 PD fMRI 神经生物学发现与恐惧神经回路假说相关联；讨论恐惧神经回路假说，并将其与认知行为疗法的发现联系起来；评论 fMRI 研究的局限性，并为未来的研究提出方法上的改变。总的来说，越来越多的证据表明，大脑结构，如前额叶皮层、前扣带皮层和边缘区域（海马体和杏仁核），可能在惊恐反应中发挥主要作用。
