用于引发惊恐障碍患者焦虑的计算机模拟在Oddball任务期间调节脑电图α波功率。
The Computer Simulation for Triggering Anxiety in Panic Disorder Patients Modulates the EEG Alpha Power during an Oddball Task.
作者信息
Silva Luiza Di Giorgio, Aprigio Danielle, Marinho Victor, Teixeira Silmar, Di Giacomo Jesse, Gongora Mariana, Budde Henning, Nardi Antonio E, Bittencourt Juliana, Cagy Mauricio, Basile Luis Fernando, Orsini Marco, Ribeiro Pedro, Velasques Bruna
机构信息
Neurophysiology and Neuropsychology of Attention Laboratory, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro 22290-140, Brazil;
Neuro-Innovation Technology & Brain Mapping Laboratory, Federal University of Delta do Parnaíba, Parnaíba 64202-020, Brazil;
出版信息
NeuroSci. 2022 May 31;3(2):332-346. doi: 10.3390/neurosci3020024. eCollection 2022 Jun.
AIM
The present study investigated the differences between the Panic Disorder (PD) patients groups' and healthy controls for the EEG alpha dynamics under the frontal cortex and reaction time during the oddball task.
MATERIAL AND METHODS
The reaction time during the oddball paradigm concomitant to EEG alpha power was tested in nine PD patients and ten healthy controls before and after a computer simulation presentation.
RESULTS
The findings revealed a decrease in EEG alpha power in PD patients concerning the control group ( ≤ 0.0125). However, both groups demonstrated an increased cortical oscillation after the computer simulation, except for the Fp1 electrode during M3 moment in the experimental group. The experimental group has a fast reaction time compared to healthy individuals during the oddball task ( = 0.002).
CONCLUSIONS
We propose that the decrease in EEG alpha power in the PD patients may indicate an increase in processing related to an anxiogenic stimulus and interference of the anxiety state that compromises the inhibitory control. The reaction time task reveals cognitive symptoms in the experimental group, which may be related to the faster reactivity and high impulsivity to stimuli.
目的
本研究调查了惊恐障碍（PD）患者组与健康对照组在额叶皮层脑电图α动力学以及Oddball任务中的反应时间方面的差异。
材料与方法
在计算机模拟呈现前后，对9名PD患者和10名健康对照者进行了与脑电图α功率相关的Oddball范式中的反应时间测试。
结果
研究结果显示，与对照组相比，PD患者的脑电图α功率降低（≤0.0125）。然而，除实验组M3时刻的Fp1电极外，两组在计算机模拟后均表现出皮层振荡增加。在Oddball任务中，实验组的反应时间比健康个体快（=0.002）。
结论
我们认为，PD患者脑电图α功率降低可能表明与焦虑源刺激相关的处理增加以及焦虑状态的干扰损害了抑制控制。反应时间任务揭示了实验组的认知症状，这可能与对刺激的更快反应性和高冲动性有关。
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