对甲基 2-辛炔酸酯的主动致敏和接触过敏。

Active sensitization and contact allergy to methyl 2-octynoate.

机构信息

National Allergy Research Centre, Department of Dermato-allergology, Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark.

出版信息

Contact Dermatitis. 2010 Feb;62(2):97-101. doi: 10.1111/j.1600-0536.2009.01664.x.

DOI:10.1111/j.1600-0536.2009.01664.x

PMID:20136892

Abstract

BACKGROUND

Methyl 2-octynoate is a synthetic fragrance which was first described to have sensitizing properties in 1935. It is one of the 26 fragrances to be labelled on the ingredient list according to current European cosmetics regulation.

OBJECTIVES

To report the experience with patch testing with methyl 2-octynoate 1% and 2% in pet.

METHODS

230 eczema patients were consecutively patch tested with 1% methyl 2-octynoate at department of Dermato-allergology Gentofte Hospital, Denmark and 120 eczema patients were consecutively patch tested with 2% M2O in Finn Chambers at the Départment de Dermatologie, CHU Saint Jacques, France.

RESULTS

Three cases of active sensitization were observed. 2 (0.87%) of the 230 Danish subjects tested with 1% in pet. and of the 120 French subjects patch tested with 2% in pet. 1 (0.83%). There was no statistical difference in active sensitization between the two groups (P = 0.72). Allergic contact dermatitis was observed in two patients (1.67%) in the French group and none in the Danish group.

CONCLUSION

Contact allergy to methyl 2-octynoate was frequently seen when patch testing with 2% in pet. However, active sensitization was also observed, when patch testing with concentrations of 1% and 2% methyl 2-octynoate. The patch test concentration should be below 1% in pet., but a safe concentration remains to be defined.

摘要

背景

甲基 2-辛炔酸甲酯是一种合成香料，于 1935 年首次被描述具有致敏特性。根据当前的欧洲化妆品法规，它是需要在成分清单上标注的 26 种香料之一。

目的

报告用 1%和 2%的甲基 2-辛炔酸甲酯进行斑贴试验的经验。

方法

丹麦 Gentofte 医院皮肤科对 230 例湿疹患者连续进行 1%甲基 2-辛炔酸甲酯斑贴试验，法国 Saint Jacques 大学医疗中心皮肤科用 Finn Chambers 对 120 例湿疹患者连续进行 2% M2O 斑贴试验。

结果

观察到 3 例活性致敏。230 名丹麦受试者中有 2 名（0.87%）用 1%的制剂在皮肤上进行斑贴试验，120 名法国受试者中有 1 名（0.83%）用 2%的制剂在皮肤上进行斑贴试验。两组之间的活性致敏无统计学差异（P = 0.72）。在法国组中有 2 名患者（1.67%）观察到过敏性接触性皮炎，而在丹麦组中则没有。